Fluorinated Pharmaceutical Intermediates
4-fluorocyclohexanone, 2,2-difluoropropanol and 2-amino-3-bromo-5-fluoropyridine are important intermediates for the synthesis of anticancer drugs, anti-leukemia drugs and antibiotic drugs, respectively, with high value and market The advantages of good prospects, but due to the current high cost of raw materials, low yield of target products and cumbersome synthetic routes, the paper re-optimizes the synthetic route of these three target compounds. The realization of low raw material cost, high product yield and the optimal reaction conditions for pilot production.
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