Basic Info:

  • Chemical Synonym(s): IOXOPROFEN; KOLOXO; Loxoprofen; Benzeneacetic acid, --methyl-4-[(2-oxocyclopentyl)methyl]-;
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  • CAS Number: 68767-14-6
  • Chemical Formula:


  • MSDS: Download


1.18 g/cm3 (20ºC)
Boiling Point
Melting Point
108.5 - 111ºC
Refractive Index
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Our company has a team of specialized pharmaceutical intermediates, and at the same time we have a wealth of plant resources, we know the reactions each plant excels at, know the waste and exhaust gases for each reaction, and understand the costs and methods of treatment. So, we can quickly match the most suitable plant for you From the material in the lab, to commercial production, we can help you get it fast. We divide the entire pharmaceutical intermediate production process into the following sections: 1. Laboratories develop routes 2. Inter test test 3. Large production shop trial production Every step we have a lot of experience and success stories

We have a 20+ year track record of working with suppliers in China and rating reports on them, and we keep our suppliers updated with the latest news so our customers can get the latest supplier reports. We know the market well and have early warning notifications on upstream raw material prices to help you build a stable supply chain.

When selecting suppliers, our procurement specialists will audit the qualification of suppliers, conduct thorough investigations such as field visits and sample testing, and make ratings to ensure the authenticity and legality of supplier information.

We have a long-term stable cooperation with GLP laboratories, encounter customer test results and supplier test results do not match the situation, we will commission a third party to test to ensure the accuracy, authenticity and reliability of the experimental results. In this way, we can effectively control the product quality problems.

We have a long-term cooperative warehouse and can follow up packaging and labeling according to safety regulations and customer requirements. In order to effectively prevent damage to the goods in transit, we have prepared various reinforcement measures and packaging solutions.

We have a number of international freight companies with whom we have long-standing cooperation, and we can choose several route options according to the customer's requirements. For more difficult or urgent orders, we will prepare several alternative solutions to ensure safe and timely delivery.


We promise to immediately and unconditionally exchange or return the goods if they have quality problems. Our employees who deal with after-sales issues have many years of international work experience and are familiar with various processes in multinational work, so they can communicate and deal with after-sales issues without any obstacles.

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Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) ,Sometimes, people also call it KOLOXO,in the propionic acid derivatives group, including ibuprofen naproxen, among others.

Like most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor and works by reducing the synthesis of prostaglandins from arachidonic acid. One of the methods to produce it is the reaction of ethyl 2-oxocyclopentanecarboxylate and potassium hydroxide in dimethylformamide with ethyl 2-(4-chloro-phenyl)propionate at 80°C for two h.

The product obtained reacts with 47% hydrobromic acid and is hydrolyzed and decarboxylated to give loxoprofen. The active chemical in Loxoprofen is Propionic. It also contains Methylparaben, Povidone Iodine, Sodium Hydroxide, Citric Acid Monohydrate.


Loxoprofen is used as an analgesic for short-term pain relief. It may also be used as systemic, cardiovascular and intra-articular treatment, such as for rheumatoid arthritis.

It is used in particular for alleviating pain and lowering fevers in conditions with inflammation or fever.

The major impacts are relieving muscle pain, delaying progression in multiple sclerosis, decreasing blood pressure, reducing excessive menstrual bleeding in women with uterine fibroids and not having side effects like other analgesics.

One unique feature is that it can also improve coughs and congestion, particularly useful for people with asthma or other lung illnesses, including chronic obstructive pulmonary disease (COPD).

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