- Chemical Synonym(s): IOXOPROFEN; KOLOXO; Loxoprofen; Benzeneacetic acid, --methyl-4-[(2-oxocyclopentyl)methyl]-;
- CAS Number: 68767-14-6
- Chemical Formula:
- MSDS: Download
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Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) ，Sometimes, people also call it KOLOXO，in the propionic acid derivatives group, including ibuprofen naproxen, among others.
Like most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor and works by reducing the synthesis of prostaglandins from arachidonic acid. One of the methods to produce it is the reaction of ethyl 2-oxocyclopentanecarboxylate and potassium hydroxide in dimethylformamide with ethyl 2-(4-chloro-phenyl)propionate at 80°C for two h.
The product obtained reacts with 47% hydrobromic acid and is hydrolyzed and decarboxylated to give loxoprofen. The active chemical in Loxoprofen is Propionic. It also contains Methylparaben, Povidone Iodine, Sodium Hydroxide, Citric Acid Monohydrate.