Irbesartan

Basic Info:

  • Chemical Synonym(s): Irbesartan; 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one; 3-Butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one; 2-Butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one;
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  • CAS Number: 138402-11-6
  • Chemical Formula:

    C25H28N6O

  • MSDS: Download

Characteristics: 

Density
1.3 g/cm3
Boiling Point
648.6ºC at 760 mmHg
Melting Point
180-181ºC
Flash Point
346ºC
Refractive Index
1.689
Vapor Pressure
Vapor Pressure
Color
white to off-white
Merck
14,5083
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Our Advantages:

Our company has a team of specialized pharmaceutical intermediates, and at the same time we have a wealth of plant resources, we know the reactions each plant excels at, know the waste and exhaust gases for each reaction, and understand the costs and methods of treatment. So, we can quickly match the most suitable plant for you From the material in the lab, to commercial production, we can help you get it fast. We divide the entire pharmaceutical intermediate production process into the following sections: 1. Laboratories develop routes 2. Inter test test 3. Large production shop trial production Every step we have a lot of experience and success stories

We have a 20+ year track record of working with suppliers in China and rating reports on them, and we keep our suppliers updated with the latest news so our customers can get the latest supplier reports. We know the market well and have early warning notifications on upstream raw material prices to help you build a stable supply chain.

When selecting suppliers, our procurement specialists will audit the qualification of suppliers, conduct thorough investigations such as field visits and sample testing, and make ratings to ensure the authenticity and legality of supplier information.

We have a long-term stable cooperation with GLP laboratories, encounter customer test results and supplier test results do not match the situation, we will commission a third party to test to ensure the accuracy, authenticity and reliability of the experimental results. In this way, we can effectively control the product quality problems.

We have a long-term cooperative warehouse and can follow up packaging and labeling according to safety regulations and customer requirements. In order to effectively prevent damage to the goods in transit, we have prepared various reinforcement measures and packaging solutions.

We have a number of international freight companies with whom we have long-standing cooperation, and we can choose several route options according to the customer's requirements. For more difficult or urgent orders, we will prepare several alternative solutions to ensure safe and timely delivery.

 

We promise to immediately and unconditionally exchange or return the goods if they have quality problems. Our employees who deal with after-sales issues have many years of international work experience and are familiar with various processes in multinational work, so they can communicate and deal with after-sales issues without any obstacles.

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Introduction:

Irbesartan (trade name: Ismo) is an inhibitor of the angiotensin-2 converting enzyme (ACE) and treats hypertension in adults.

Irbesartan can be produced in a 3 step reaction starting with 2-bromobenzoic acid for hydrogenation, adding two methoxy benzaldehyde and then exposure to sodium hydroxide in methanolic solution.

The final product will have three chiral centres: R(1), S(2) and D(3).  it is also produced by reacting irbesartan with 4-Bromo-3,5-dimethoxybenzoic acid in suspension at different concentrations.

The process involves an esterification reaction that leaves Irbesartan to be purified through column chromatography and vacuum distillation. Irbesartan blocks the uptake of salt across blood vessel walls with very few side effects, which raises blood pressure. The active ingredients are irbesartan, an angiotensin II receptor antagonist, and hydralazine HCL, a vasodilator. 

Applications:

Irbesartan is an orally active, potent and competitive antagonist of the angiotensin II type 1 receptor AT1. It has been used for congestive heart failure and to treat high blood pressure.

Its effects on blood pressure are proportional to the current stage of hypertension, and it can be utilized as a partner with other medications for cases of resistant hypertension. Irbesartan was originally identified through its component erythromycin and then later processed and sold as erythrohydne, but now only remains in research currently.

It has been shown to inhibit TGF beta1 production by blocking the binding between Smad3/Smad4 complexes. In turn, this inhibits TGF beta1 from activating downstream signaling pathways such as the Mitogen-Activated Protein Kinases (MAPK) family of kinases.

It's often used as an active ingredient and has attracted attention because of its benefits for relieving pain and reducing swelling without any harmful side effects.  Irbesartan components can be made into tablets or capsules.

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