Gemcitabine

Basic Info:

  • Chemical Synonym(s): 4-AMINO-1-[(2R,4R,5R)-3,3-DIFLUORO-4-HYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]PYRIMIDIN-2-ONE; GEMCITABINE HCL; GEMCITABINE, FREE BASE; 2'-DESOXY-2',2'-DIFLUORCYTIDINE; 3-DEOXY-2,2-DIFLUORO-D-RIBOFURANOSE-3,5-DIBENZOATE; Expand
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  • CAS Number: 95058-81-4
  • Chemical Formula:

    C9H11F2N3O4

Characteristics: 

Melting Point
168.64°C
Alpha
365 +425.36°; D +71.51°
Boiling point
482.7±55.0 °C(Predicted)
Density
1.84±0.1 g/cm3(Predicted)
Storage temp.
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Pka
11.65±0.70(Predicted)
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Our Advantages:

Our company has a team of specialized pharmaceutical intermediates, and at the same time we have a wealth of plant resources, we know the reactions each plant excels at, know the waste and exhaust gases for each reaction, and understand the costs and methods of treatment.

So, we can quickly match the most suitable plant for you From the material in the lab, to commercial production, we can help you get it fast.

We divide the entire pharmaceutical intermediate production process into the following sections: 1. Laboratories develop routes 2. Inter test test 3. Large production shop trial production Every step we have a lot of experience and success stories

We have a 20+ year track record of working with suppliers in China and rating reports on them, and we keep our suppliers updated with the latest news so our customers can get the latest supplier reports. We know the market well and have early warning notifications on upstream raw material prices to help you build a stable supply chain.

When selecting suppliers, our procurement specialists will audit the qualification of suppliers, conduct thorough investigations such as field visits and sample testing, and make ratings to ensure the authenticity and legality of supplier information.

We have a long-term stable cooperation with GLP laboratories, encounter customer test results and supplier test results do not match the situation, we will commission a third party to test to ensure the accuracy, authenticity and reliability of the experimental results. In this way, we can effectively control the product quality problems.

We have a long-term cooperative warehouse and can follow up packaging and labeling according to safety regulations and customer requirements. In order to effectively prevent damage to the goods in transit, we have prepared various reinforcement measures and packaging solutions.

We have a number of international freight companies with whom we have long-standing cooperation, and we can choose several route options according to the customer's requirements. For more difficult or urgent orders, we will prepare several alternative solutions to ensure safe and timely delivery.

 

We promise to immediately and unconditionally exchange or return the goods if they have quality problems. Our employees who deal with after-sales issues have many years of international work experience and are familiar with various processes in multinational work, so they can communicate and deal with after-sales issues without any obstacles.

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Introduction:

Gemcitabine is one of the most widely used anticancer drugs. It is usually administered intravenously. It belongs to a class of chemotherapy drugs called nucleoside analogues.

However, it can also affect healthy cells and cause some side effects. It is an analogue of 2'-deoxycytidine. Gemcitabine reduces the growth of tumour cells in the body by stopping them from dividing. It is used in combination with other cancer medicines for treating pancreatic cancer.

It is synthetic drugs that affect DNA and RNA.  Its common nicknames are: Gemzar, Lielzepine, Cisplatin. It is manufactured by nucleophilic substitution of 2-aminopurine with 5-fluorouracil. It primarily targets the mitochondria of the cell with which it comes in contact.

This makes it relatively non-toxic to healthy cells but very effective at killing cancer cells since mitochondria are present in most body cells.

Applications:

Gemcitabine is used in the treatment of various types of cancer. It is used to treat breast cancer, pancreatic cancer, non-small cell lung cancer (NSCLC) and colorectal cancer.

Gemcitabine is also used to treat tumours that become resistant to other chemotherapy agents. The effectiveness of this drug has been seen in clinical trials where Gemcitabine is used in conjunction with other drugs like fluorouracil (5-FU), Taxotere, and docetaxel. Gemcitabine is used to treat cancer of the pancreas.

Pancreatic cancer is cancer that starts in cells in the pancreas. This is also an effective drug for treating many types of cancer. Another application of Gemcitabine is the treatment of advanced non-small-cell lung cancer.

It is part of the family of chemotherapy drugs, recommended as a first-line treatment for those with advanced pancreatic cancer. It is also used as a second-line treatment after the failure of Cisplatin and 5-fluorouracil. 

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